Benefits of ketogenic diets against cancer

It’s been proposed that ketogenic diets may be beneficial against cancer, because cancer cells are highly dependent on glucose metabolism and, in test tubes, frequently die if they are obliged to use ketones or fats for energy.

Consumption of short-chain fats for ketone generation, along with carb restriction, can lower blood glucose levels while still nourishing neurons with ketones.

A ketogenic diet recently tested in cancer therapy consisted of 60 percent medium-chain fats, 10 percent longer-chain fats, 10 percent carbs, and 20 percent protein.

So far, at least, positive results have only been reported for ketogenic diets in brain cancer. There are case reports of ketogenic diets reducing tumor activity and halting brain cancer progression.

However, studies of ketogenic diets in other cancers have been disappointing. Here are the results of a pilot trial in which sixteen patients with advanced metastatic cancer were put on ketogenic diets:

One patient did not tolerate the diet and dropped out within 3 days. Among those who tolerated the diet, two patients died early, one stopped after 2 weeks due to personal reasons, one felt unable to stick to the diet after 4 weeks, one stopped after 6 and two stopped after 7 and 8 weeks due to progress of the disease, one had to discontinue after 6 weeks to resume chemotherapy and five completed the 3-month intervention period.

A possible reason why ketogenic diets may work well in brain cancers but not other cancers is that tumors in the body may evade the metabolic restrictions of a ketogenic diet by manipulating neighboring normal cells into providing them with lactic acid, which the cancer cells can metabolize.

However, ketogenic diets may still be a valuable adjunct to chemotherapy. Fasting prior to chemotherapy reduces toxicity to normal cells but increases toxicity to cancer cells. Fasting is ketogenic, and a ketogenic diet might have the same effect during chemotherapy.

Benefits of ketogenic diets against cancer
Source:  Perfect Health Diet - Paul Jaminet, Ph.D